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The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities
المؤلفون المشاركون
Majkowska, Lilianna
Safranow, Krzysztof
Homa, Katarzyna
Syrenicz, Anhelli
Molęda, Piotr
Fronczyk, Aneta
Stefański, Adam
Bińczak-Kuleta, Agnieszka
Celewicz, Zbigniew
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM).
Material and Methods.
Study group included 199 women, diagnosed GDM within the last 5–12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy.
Blood glucose and insulin levels were measured during oral glucose tolerance test.
Indices of insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were calculated.
In all patients, the C49620T polymorphism in intron 15 of the SUR1 gene was determined.
Results.
The distribution of the studied polymorphism in the two groups did not differ from each other (χ2 = 0.34, P=0.8425).
No association between the distribution of polymorphisms and coexisting glucose metabolism disorders (χ2 = 7,13, P=0,3043) was found.
No association was also observed between the polymorphism and HOMA %B or HOMA-IR.
Conclusions.
The polymorphism C49620T in the SUR1 gene is not associated with insulin resistance and/or insulin secretion in women with a history of GDM and does not affect the development of GDM, or the development of glucose intolerance in the studied population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Molęda, Piotr& Bińczak-Kuleta, Agnieszka& Homa, Katarzyna& Safranow, Krzysztof& Celewicz, Zbigniew& Syrenicz, Anhelli…[et al.]. 2012. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492552
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Molęda, Piotr…[et al.]. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-492552
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Molęda, Piotr& Bińczak-Kuleta, Agnieszka& Homa, Katarzyna& Safranow, Krzysztof& Celewicz, Zbigniew& Syrenicz, Anhelli…[et al.]. The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492552
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492552
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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