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Cortisol Is an Associated-Risk Factor of Brain Dysfunction in Patients with Severe Sepsis and Septic Shock
المؤلفون المشاركون
Huyghens, Luc
Vincent, Jean-Louis
Zhang, Haibo
Schiettecatte, Johan
Nguyen, Duc Nam
Smitz, Johan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate cortisol levels in brain dysfunction in patients with severe sepsis and septic shock.
Methods.
In 128 septic and sedated patients, we studied brain dysfunction including delirium and coma by the evaluation of Richmond Agitation Sedation Scale (RASS), the Confusion Method Assessment in the ICU (CAM-ICU) after sedation withdrawal and the measurement of serum S100B biomarker of brain injury.
Serum cortisol and S100B were measured within 12 hours after ICU admission and daily over the next four days.
Results.
Brain dysfunction was observed in 50% (64/128) before but in 84% (107/128) of patients after sedation withdrawal, and was more common in the patients older than 57 years (P = 0.009).
Both cortisol (P = 0.007) and S100B levels (P = 0.028) were higher in patients with than patients without brain dysfunction.
Cortisol levels were associated with ICU mortality (hazard ratio = 1.17, P = 0.024).
Multivariate logistic regression showed that cortisol (odds ratio (OR): 2.34, 95% CI (2.01, 3.22), P = 0.02) and the combination effect of cortisol with age (OR: 1.004, 95% CI (1.002, 1.93), P = 0.038) but not S100B were associated with brain dysfunction.
Conclusions.
Cortisol was an associated-risk factor of brain dysfunction in patients with severe sepsis and septic shock.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nguyen, Duc Nam& Huyghens, Luc& Zhang, Haibo& Schiettecatte, Johan& Smitz, Johan& Vincent, Jean-Louis. 2014. Cortisol Is an Associated-Risk Factor of Brain Dysfunction in Patients with Severe Sepsis and Septic Shock. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492566
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nguyen, Duc Nam…[et al.]. Cortisol Is an Associated-Risk Factor of Brain Dysfunction in Patients with Severe Sepsis and Septic Shock. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-492566
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nguyen, Duc Nam& Huyghens, Luc& Zhang, Haibo& Schiettecatte, Johan& Smitz, Johan& Vincent, Jean-Louis. Cortisol Is an Associated-Risk Factor of Brain Dysfunction in Patients with Severe Sepsis and Septic Shock. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492566
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492566
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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