Evaluation of Prognostic Significance of Circulating Tumor Cells Detection in Rectal Cancer Patients Treated with Preoperative Radiotherapy : Prospectively Collected Material Data
المؤلفون المشاركون
Nesteruk, Dominika
Pawlak, Jacek
Fabisiewicz, Stanisław
Fabisiewicz, Anna
Rutkowski, Andrzej
Siedlecki, Janusz A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the prognostic value of circulating tumor cells (CTC) in nonmetastatic rectal cancer patients treated with short-term preoperative radiotherapy.
In this single-center trial, 162 patients with rectal cancer after preoperative short-term radiotherapy (5×5 Gy) were recruited from January, 2008 to September, 2011.
Clearance of CTC was determined in 91 patients enrolled in the molecular analysis.
CTC presence was evaluated with real-time reverse transcription polymerase chain reaction assay (qPCR) based on the expression of three tumor genetic markers: carcinoembryonic antigen (CEA), cytokeratin 20 (CK20), and/or cancer stem cells marker CD133 (CEA/CK20/CD133).
We found that CTC detection 7 days after surgery was of prognostic significance for the local recurrence (P value = 0.006).
CTC detected preoperatively and 24 hours after resection had no prognostic value in cancer recurrence; however, there was a significant relationship between CTC prevalence 24 hours after surgery and lymph node metastasis (pN1-2).
We also confirmed a significant clearance of CTC in peripheral blood (PB) 24 hours after surgery.
Preoperative sampling is not significant for prognosis in rectal cancer patients treated with short-term radiotherapy.
Detection of CTC in PB 7 days after surgery is an independent factor predicting local recurrence in this group of patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nesteruk, Dominika& Rutkowski, Andrzej& Fabisiewicz, Stanisław& Pawlak, Jacek& Siedlecki, Janusz A.& Fabisiewicz, Anna. 2014. Evaluation of Prognostic Significance of Circulating Tumor Cells Detection in Rectal Cancer Patients Treated with Preoperative Radiotherapy : Prospectively Collected Material Data. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-492574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nesteruk, Dominika…[et al.]. Evaluation of Prognostic Significance of Circulating Tumor Cells Detection in Rectal Cancer Patients Treated with Preoperative Radiotherapy : Prospectively Collected Material Data. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-492574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nesteruk, Dominika& Rutkowski, Andrzej& Fabisiewicz, Stanisław& Pawlak, Jacek& Siedlecki, Janusz A.& Fabisiewicz, Anna. Evaluation of Prognostic Significance of Circulating Tumor Cells Detection in Rectal Cancer Patients Treated with Preoperative Radiotherapy : Prospectively Collected Material Data. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-492574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر