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Tract-Based Spatial Statistics : Application to Mild Cognitive Impairment
المؤلفون المشاركون
Lee, Jiann-Der
Wang, Jiun-Jie
Tsai, Ming-Lun
Lin, Yu-Chun
Fung, Hon-Chung
Ying, Leslie
Wu, Yih-Ru
Hsu, Wen-Chuin
Wai, Yau-Yau
Chan, Hsiao-Lung
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Rationale and Objectives.
The primary objective of the current investigation was to characterize white matter integrity in different subtypes of mild cognitive impairment (MCI) using tract-based spatial statistics of diffusion tensor imaging.
Materials and Methods.
The study participants were divided into 4 groups of 30 subjects each as follows: cognitively healthy controls, amnestic MCI, dysexecutive MCI, and Alzheimer’s disease (AD).
All subjects underwent a comprehensive neuropsychological assessment, apolipoprotein E genotyping, and 3-tesla MRI.
The diffusion tensor was reconstructed and then analyzed using tract-based spatial statistics.
The changes in brain white matter tracts were also examined according to the apolipoprotein E ε4 status.
Results.
Compared with controls, amnestic MCI patients showed significant differences in the cerebral white matter, where changes were consistently detectable in the frontal and parietal lobes.
We found a moderate impact of the apolipoprotein E ε4 status on the extent of white matter disruption in the amnestic MCI group.
Patients with AD exhibited similar but more extensive alterations, while no significant changes were observed in dysexecutive MCI patients.
Conclusion.
The results from this study indicate that amnestic MCI is the most likely precursor to AD as both conditions share significant white matter damage.
By contrast, dysexecutive MCI seems to be characterized by a distinct pathogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wai, Yau-Yau& Hsu, Wen-Chuin& Fung, Hon-Chung& Lee, Jiann-Der& Chan, Hsiao-Lung& Tsai, Ming-Lun…[et al.]. 2014. Tract-Based Spatial Statistics : Application to Mild Cognitive Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492597
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wai, Yau-Yau…[et al.]. Tract-Based Spatial Statistics : Application to Mild Cognitive Impairment. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-492597
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wai, Yau-Yau& Hsu, Wen-Chuin& Fung, Hon-Chung& Lee, Jiann-Der& Chan, Hsiao-Lung& Tsai, Ming-Lun…[et al.]. Tract-Based Spatial Statistics : Application to Mild Cognitive Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492597
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492597
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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