The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
المؤلفون المشاركون
Yu, Peng-Fei
Eerdun, Gaowa
Zhang, Lei-Ming
Li, Chong
Fu, Feng-Hua
Wang, Wen-Yan
Wang, Tian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Danshensu (3-(3, 4-dihydroxyphenyl) lactic acid), a water-soluble active component isolated from the root of Salvia miltiorrhiza Bunge, is widely used for the treatment of cerebrovascular diseases.
The present study aims to investigate the role of P-glycoprotein in transport of Danshensu across the blood-brain barrier.
Sprague-Dawley rats were pretreated with verapamil at a dose of 20 mg kg−1 (verapamil group) or the same volume of normal saline (control group).
Ninety minutes later, the animals were administrated with Danshensu (15 mg kg−1) by intravenous injection.
At 15 min, 30 min, and 60 min after Danshensu administration, the levels of Danshensu in the blood and brain were detected by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
The results showed that Danshensu concentrations in the brain of the rats pretreated with verapamil were significantly increased.
In addition, the brain-plasma ratios of the group pretreated with verapamil were much higher than that of the control group.
There was no difference in Danshensu level in plasma between the verapamil group and control group.
The findings indicated that Danshensu can pass the blood-brain barrier, and P-glycoprotein plays an important role in Danshensu transportation in brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Peng-Fei& Wang, Wen-Yan& Eerdun, Gaowa& Wang, Tian& Zhang, Lei-Ming& Li, Chong…[et al.]. 2011. The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492631
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Peng-Fei…[et al.]. The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-492631
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Peng-Fei& Wang, Wen-Yan& Eerdun, Gaowa& Wang, Tian& Zhang, Lei-Ming& Li, Chong…[et al.]. The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492631
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492631
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر