The Efficacy and Safety of Propiverine Hydrochloride in Patients with Overactive Bladder Symptoms Who Poorly Responded to Previous Anticholinergic Agents
المؤلفون المشاركون
Oda, Toshiro
Masumori, Naoya
Iwasawa, Akihiko
Sato, Takashi
Tsukamoto, Taiji
Miyamoto, Shintaro
Itoh, Naoki
Furuya, Ryoji
Shibuya, Akihiko
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-28
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objectives.
To prospectively examine the efficacy and safety of propiverine hydrochloride in patients with overactive bladder (OAB) symptoms who poorly responded to previous treatment with solifenacin, tolterodine or imidafenacin.
Methods.
Patients aged ≥20 with persisting OAB symptoms (≥6 in OAB symptom score (OABSS)) even after at least 4-week treatment using solifenacin, tolterodine or imidafenacin were enrolled.
Propiverine 20 mg/day was administered for 12 weeks to 70 patients who desired the further improvement of OAB symptoms and 3 who had intolerable adverse events of previous drugs.
The OABSS and postvoid residual urine volume (PVR) were determined before and at 4 and 12 weeks of treatment.
Results.
Of 73 patients enrolled (29 males and 44 females, median age 71 years), 52 completed the protocol treatment.
The OABSS was significantly improved by propiverine treatment (9.0 at baseline, 6.2 at 4 weeks, 6.3 at 12 weeks (P<0.001)).
The scores of OAB symptoms (nighttime frequency, urgency and urge incontinence) except daytime frequency also improved significantly.
No increase in PVR was observed.
The most frequent adverse event was dry mouth (13.7%), followed by constipation (6.8%).
Conclusions.
Propiverine is useful to improve OAB for patients who poorly respond to solifenacin, tolterodine or imidafenacin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masumori, Naoya& Miyamoto, Shintaro& Tsukamoto, Taiji& Furuya, Ryoji& Iwasawa, Akihiko& Sato, Takashi…[et al.]. 2011. The Efficacy and Safety of Propiverine Hydrochloride in Patients with Overactive Bladder Symptoms Who Poorly Responded to Previous Anticholinergic Agents. Advances in Urology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-492753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masumori, Naoya…[et al.]. The Efficacy and Safety of Propiverine Hydrochloride in Patients with Overactive Bladder Symptoms Who Poorly Responded to Previous Anticholinergic Agents. Advances in Urology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-492753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masumori, Naoya& Miyamoto, Shintaro& Tsukamoto, Taiji& Furuya, Ryoji& Iwasawa, Akihiko& Sato, Takashi…[et al.]. The Efficacy and Safety of Propiverine Hydrochloride in Patients with Overactive Bladder Symptoms Who Poorly Responded to Previous Anticholinergic Agents. Advances in Urology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-492753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر