Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats

المؤلفون المشاركون

Cheng, Neng-neng
Shi, Rong
Zan, Bin
Ma, Bing-liang
Zhong, Jie
Qiu, Fu-rong
Ma, Yue-ming
Wu, Jia-sheng
Wang, Tian-ming
Lu, Xiong

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-07-02

دولة النشر

مصر

عدد الصفحات

15

التخصصات الرئيسية

الطب البشري

الملخص EN

In Chinese medicine, Xiexin decoction (XXD) has been used for the clinical treatment of diabetes for at least 1700 years.

The present study was conducted to investigate the effective ingredients of XXD and their molecular mechanisms of antidiabetic nephropathy in rats.

Rats with diabetes induced by high-fat diet and streptozotocin were treated with XXD extract for 12 weeks.

XXD significantly improved the glucolipid metabolism disorder, attenuated albuminuria and renal pathological changes, reduced renal advanced glycation end-products, inhibited receptor for advanced glycation end-product and inflammation factors expression, suppressed renal nuclear factor-κB pathway activity, and downregulated renal transforming growth factor-β1.

The concentrations of multiple components in plasma from XXD were determined by liquid chromatography and tandem mass spectrometry.

Pharmacokinetic/pharmacodynamic analysis using partial least square regression revealed that 8 ingredients of XXD were responsible for renal protective effects via actions on multiple molecular targets.

Our study suggests that the renal protective role of XXD with multiple effective ingredients involves inhibition of inflammation through downregulation of the nuclear factor-κB pathway, reducing renal advanced glycation end-products and receptor for advanced glycation end-product in diabetic rats.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Jia-sheng& Shi, Rong& Zhong, Jie& Lu, Xiong& Ma, Bing-liang& Wang, Tian-ming…[et al.]. 2013. Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-492822

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Jia-sheng…[et al.]. Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-492822

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Jia-sheng& Shi, Rong& Zhong, Jie& Lu, Xiong& Ma, Bing-liang& Wang, Tian-ming…[et al.]. Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-492822

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-492822