Methadone-Induced Delayed Posthypoxic Encephalopathy : Clinical, Radiological, and Pathological Findings

المؤلفون المشاركون

Wang, Yunxia
Mittal, Manoj
Reeves, Alan
Newell, Kathy

المصدر

Case Reports in Medicine

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-12-09

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الطب البشري

الملخص EN

Objective.

To describe the clinical, radiological and pathological findings in a patient with methadone-induced delayed posthypoxic encephalopathy (DPHE).

Case Report.

A Thirty-eight-year-old man was found unconscious for an unknown duration after methadone and diazepam ingestion.

His initial vitals were temperature 104 degree Fahrenheit, heart rate 148/minute, respiratory rate 50/minute, and blood pressure 107/72 mmhg.

He developed renal failure, rhabdomyolysis, and elevated liver enzymes which resolved completely in 6 days.

After 2 weeks from discharge he had progressive deterioration of his cognitive, behavioral and neurological function.

Brain MRI showed diffuse abnormal T2 signal in the corona radiata, centrum semiovale, and subcortical white matter throughout all lobes.

Extensive work up was negative for any metabolic, infectious or autoimmune disorder.

Brain biopsy showed significant axonal injury in the white matter.

He was treated successfully with combination of steroids and antioxidants.

Follow up at 2 year showed no residual deficits.

Conclusion.

Our observation suggests that patients on methadone therapy should be monitored for any neurological or psychiatric symptoms, and in suspected cases MRI brain may help to make the diagnosis of DPHE.

A trial of steroids and antioxidants may be considered in these patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mittal, Manoj& Wang, Yunxia& Reeves, Alan& Newell, Kathy. 2010. Methadone-Induced Delayed Posthypoxic Encephalopathy : Clinical, Radiological, and Pathological Findings. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-492914

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mittal, Manoj…[et al.]. Methadone-Induced Delayed Posthypoxic Encephalopathy : Clinical, Radiological, and Pathological Findings. Case Reports in Medicine No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-492914

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mittal, Manoj& Wang, Yunxia& Reeves, Alan& Newell, Kathy. Methadone-Induced Delayed Posthypoxic Encephalopathy : Clinical, Radiological, and Pathological Findings. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-492914

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-492914