Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
المؤلفون المشاركون
Lu, Lina
Zheng, Ningning
Wu, Hongbing
Wang, Xiaoxian
Xin, Xue
Su, Jing
Zou, Haimiao
Qiu, Mingfeng
Wang, Xiaoyan
Liu, Yinmin
Xu, Xinchun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Coronary heart disease (CHD) is one of the highest mortality diseases in the world.
Traditional Chinese medicine compound Danshen dripping pills (CDDPs) have currently made a great achievement in treating CHD.
However, the therapeutic mechanism of CDDP is often poorly interpreted.
In this study, a GC-MS-based metabonomic study was conducted to assess the holistic efficacy of CDDP for myocardial infarction in male Sprague-Dawley rats, which were divided into the control group, the sham group, the model group, the control + CDDP group, and the model + CDDP, with CDDP at a dose of 107 mg/kg·d (equal to 1.8 mL/kg·d).
The metabonomic findings demonstrated great differences of metabolic pattern among sham, model, and the model + CDDP in the orthogonal partial least squares discriminant analysis (OPLS-DA) models, which coordinated well with the assessment of plasma biochemistry and histopathological assay.
Differentially expressed metabolites suggested that energy metabolism, glycolysis, and lipid metabolism might be disrupted by myocardial infarction.
Both the potential metabolic biomarkers and the biochemical histopathological indices were regulated effectively by CDDP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xin, Xue& Zou, Haimiao& Zheng, Ningning& Xu, Xinchun& Liu, Yinmin& Wang, Xiaoxian…[et al.]. 2013. Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xin, Xue…[et al.]. Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-493057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xin, Xue& Zou, Haimiao& Zheng, Ningning& Xu, Xinchun& Liu, Yinmin& Wang, Xiaoxian…[et al.]. Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر