Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum

الملخص EN

Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account.

We report a 21-year-old woman that suffered gait instability, headache, and diplopia.

On CT-scan, an intraparenchymatous cerebellar tumor was disclosed.

It was isodense, showing light enhancement after contrast administration.

On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration.

On T2-weighted MRI, the tumor was inhomogenously hyperintense.

At surgery, a solid and hypervascularized tumor was completely removed.

Two years after surgery, the patient is symptom-free.

Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified.

These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified.

A complex form variant of DNT was diagnosed.

Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered.