Development of a Murine Model of Early Sepsis in Diet-Induced Obesity
المؤلفون المشاركون
Patrick, Amanda L.
Fox-Robichaud, Alison E.
Translational Biology Group, The Canadian Critical Care
Khan, Momina
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Sepsis, a global health issue, is the most common cause of mortality in the intensive care unit.
The aim of this study was to develop a new model of sepsis that investigates the impact of prolonged western diet (WD) induced obesity on the response to early sepsis.
Male C57BL/6 mice were fed either a high fat WD or normal chow diet (NCD) for 6, 15, or 27 weeks.
Septic obese mice at 15 and 27 weeks had significantly lower levels of lung myeloperoxidase (26.3 ± 3.80 U/mg tissue) compared to age matched ad lib (44.1 ± 2.86 U/mg tissue) and diet restricted (63.2 ± 5.60 U/mg tissue) controls.
Low levels of lung inflammation were not associated with changes in hepatic cytokines and oxidative stress levels.
Obese mice had significantly (P<0.0001) larger livers compared to controls.
Histological examination of the livers demonstrated that WD fed mice had increased inflammation with pronounced fat infiltration, steatosis, and hepatocyte ballooning.
Using this model of prolonged exposure to high fat diet we have data that agree with recent clinical observations suggesting obese individuals are protected from sepsis-induced lung injury.
This model will allow us to investigate the links between damage to the hepatic microcirculation, immune response, and lung injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Momina& Patrick, Amanda L.& Fox-Robichaud, Alison E.& Translational Biology Group, The Canadian Critical Care. 2014. Development of a Murine Model of Early Sepsis in Diet-Induced Obesity. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Momina…[et al.]. Development of a Murine Model of Early Sepsis in Diet-Induced Obesity. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-493210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Momina& Patrick, Amanda L.& Fox-Robichaud, Alison E.& Translational Biology Group, The Canadian Critical Care. Development of a Murine Model of Early Sepsis in Diet-Induced Obesity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر