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Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination
المؤلفون المشاركون
Glausser, Margaret K.
Thissen, James B.
McLoughlin, Kevin S.
Jaing, Crystal J.
Hewitson, Laura
Gardner, Shea N.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In 2010, researchers reported that the two US-licensed rotavirus vaccines contained DNA or DNA fragments from porcine circovirus (PCV).
Although PCV, a common virus among pigs, is not thought to cause illness in humans, these findings raised several safety concerns.
In this study, we sought to determine whether viruses, including PCV, could be detected in ileal tissue samples of children vaccinated with one of the two rotavirus vaccines.
A broad spectrum, novel DNA detection technology, the Lawrence Livermore Microbial Detection Array (LLMDA), was utilized, and confirmation of viral pathogens using the polymerase chain reaction (PCR) was conducted.
The LLMDA technology was recently used to identify PCV from one rotavirus vaccine.
Ileal tissue samples were analyzed from 21 subjects, aged 15–62 months.
PCV was not detected in any ileal tissue samples by the LLMDA or PCR.
LLMDA identified a human rotavirus A from one of the vaccinated subjects, which is likely due to a recent infection from a wild type rotavirus.
LLMDA also identified human parechovirus, a common gastroenteritis viral infection, from two subjects.
Additionally, LLMDA detected common gastrointestinal bacterial organisms from the Enterobacteriaceae, Bacteroidaceae, and Streptococcaceae families from several subjects.
This study provides a survey of viral and bacterial pathogens from pediatric ileal samples, and may shed light on future studies to identify pathogen associations with pediatric vaccinations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hewitson, Laura& Thissen, James B.& Gardner, Shea N.& McLoughlin, Kevin S.& Glausser, Margaret K.& Jaing, Crystal J.. 2014. Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination. Advances in Virology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-493256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hewitson, Laura…[et al.]. Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination. Advances in Virology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-493256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hewitson, Laura& Thissen, James B.& Gardner, Shea N.& McLoughlin, Kevin S.& Glausser, Margaret K.& Jaing, Crystal J.. Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination. Advances in Virology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-493256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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