Serial Serum Leukocyte Apoptosis Levels as Predictors of Outcome in Acute Traumatic Brain Injury
المؤلفون المشاركون
Wang, Hung-Chen
Yang, Tzu-Ming
Kwan, Aij-Lie
Lu, Cheng-Hsien
Lin, Yu-Tsai
Lin, Yu-Jun
Ho, Jih-Tsun
Chen, Wu-Fu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Apoptosis associates with secondary brain injury after traumatic brain injury (TBI).
This study posits that serum leukocyte apoptosis levels in acute TBI are predictive of outcome.
Methods.
Two hundred and twenty-nine blood samples from 88 patients after acute TBI were obtained on admission and on Days 4 and 7.
Serial apoptosis levels of different leukocyte subsets were examined in 88 TBI patients and 27 control subjects.
Results.
The leukocyte apoptosis was significantly higher in TBI patients than in controls.
Brief unconsciousness (P=0.009), motor deficits (P≤0.001), GCS (P≤0.001), ISS (P=0.001), WBC count (P=0.015), late apoptosis in lymphocytes and monocytes on Day 1 (P=0.004 and P=0.022, resp.), subdural hemorrhage on initial brain CT (P=0.002), neurosurgical intervention (P≤0.001), and acute posttraumatic seizure (P=0.046) were significant risk factors of outcome.
Only motor deficits (P=0.033) and late apoptosis in monocytes on Day 1 (P=0.037) were independently associated with outcome.
A cutoff value of 5.72% of late apoptosis in monocytes was associated with poor outcome in acute TBI patients.
Conclusion.
There are varying degrees of apoptosis in patients following TBI and in healthy individuals.
Such differential expression suggests that apoptosis in different leukocyte subsets plays an important role in outcome following injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hung-Chen& Yang, Tzu-Ming& Lin, Yu-Jun& Chen, Wu-Fu& Ho, Jih-Tsun& Lin, Yu-Tsai…[et al.]. 2014. Serial Serum Leukocyte Apoptosis Levels as Predictors of Outcome in Acute Traumatic Brain Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hung-Chen…[et al.]. Serial Serum Leukocyte Apoptosis Levels as Predictors of Outcome in Acute Traumatic Brain Injury. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-493289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hung-Chen& Yang, Tzu-Ming& Lin, Yu-Jun& Chen, Wu-Fu& Ho, Jih-Tsun& Lin, Yu-Tsai…[et al.]. Serial Serum Leukocyte Apoptosis Levels as Predictors of Outcome in Acute Traumatic Brain Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر