Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity
المؤلفون المشاركون
Juang, Shin-Hun
Tsai, Shang-Yuan
Ho, Lu-Ching
Chao, Pei-Dawn Lee
Shia, Chi-Sheng
Hou, Yu-Chi
Hsieh, Pei-Hsun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
San-Huang-Xie-Xin-Tang (SHXXT), a widely used Chinese herbal formula, consists of rhizomes of Rheum officinale, roots of Scutellaria baicalensis and rhizomes of Coptis chinesis.
This study investigated the metabolism and pharmacokinetics of polyphenols in SHXXT, including baicalin, baicalein, wogonin, emodin, aloe-emodin, rhein and chrysophanol.
The quantitation methods of SHXXT decoction and rat serum using high performance liquid chromatography were developed and validated in this study.
After oral administration of SHXXT decoction to rats, the parent forms of various constituents and their conjugated metabolites in serum were determined before and after hydrolysis with β-glucuronidase and sulfatase.
The results showed that only free form of rhein can be quantitated, whereas the parent forms of coptisine, palmatine, berberine, baicalein, wogonin, emodin, aloe-emodin and chrysophanol were not detected in serum.
The glucuronides of baicalein, wogonin, emodin, aloe-emodin, rhein and chrysophanol were the predominant forms in bloodstream.
In order to evaluate the in vivo antioxidant activity of SHXXT, the serum metabolite of SHXXT was prepared, characterized and followed by evaluation of the effect on AAPH-induced hemolysis.
The results indicated that metabolites of SHXXT exhibited significant free radical scavenging activity.
We suggest that biologists redirect their focus to the bioactivity of the conjugated metabolites of these polyphenols.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shia, Chi-Sheng& Hou, Yu-Chi& Juang, Shin-Hun& Tsai, Shang-Yuan& Hsieh, Pei-Hsun& Ho, Lu-Ching…[et al.]. 2011. Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shia, Chi-Sheng…[et al.]. Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-493316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shia, Chi-Sheng& Hou, Yu-Chi& Juang, Shin-Hun& Tsai, Shang-Yuan& Hsieh, Pei-Hsun& Ho, Lu-Ching…[et al.]. Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر