BCG and BCGDNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis
المؤلفون المشاركون
Silva, Célio Lopes
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Masson, Ana Paula
Zorzella-Pezavento, Sofia Fernanda Gonçalves
Guerino, Clara Pires Fujiara
França, Thais Graziela Donegá
Sartori, Alexandrina
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A prime-boost strategy conserving BCG is considered the most promising vaccine to control tuberculosis.
A boost with a DNA vaccine containing the mycobacterial gene of a heat shock protein (pVAXhsp65) after BCG priming protected mice against experimental tuberculosis.
However, anti-hsp65 immunity could worsen an autoimmune disease due to molecular mimicry.
In this investigation, we evaluated the effect of a previous BCG or BCG/pVAXhsp65 immunization on experimental autoimmune encephalomyelitis (EAE) development.
Female Lewis rats were immunized with BCG or BCG followed by pVAXhsp65 boosters.
The animals underwent EAE induction and were daily evaluated for weight loss and clinical score.
They were euthanized during recovery phase to assess immune response and inflammatory infiltration at the central nervous system.
Previous immunization did not aggravate or accelerate clinical score or weight loss.
In addition, this procedure clearly decreased inflammation in the brain.
BCG immunization modulated the host immune response by triggering a significant reduction in IL-10 and IFN-γ levels induced by myelin basic protein.
These data indicated that vaccination protocols with BCG or BCG followed by boosters with pVAXhsp65 did not trigger a deleterious effect on EAE evolution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Guerino, Clara Pires Fujiara& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& Masson, Ana Paula…[et al.]. 2013. BCG and BCGDNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493327
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. BCG and BCGDNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-493327
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Guerino, Clara Pires Fujiara& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& Masson, Ana Paula…[et al.]. BCG and BCGDNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493327
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493327
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر