Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
Jiang, Yan-Fang
Zou, Qi
Sun, Bowen
Wang, Man
Li, Xiaodan
Tang, Ying
Xu, Lijun
Zhao, Shasha
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
T cells and B cells participate in the pathogenesis of COPD.
Currently, NK cells and NKT cells have gained increasing attention.
In the present study, 19 COPD patients and 12 healthy nonsmokers (HNS) were recruited, and their pulmonary function was assessed.
The frequencies of CD3+ T, CD4+ T, CD8+ T, B, NK, and NKT-like cells were determined using flow cytometry.
The frequencies of spontaneous and inducible IFN-γ+ or CD107a+ NK and NKT-like cells as well as activating or inhibitory receptors were also detected.
The potential association of lymphocyte subsets with disease severity was further analyzed.
Significantly decreased numbers of CD3+ and CD4+ T cells, and the CD4+/CD8+ ratio, but increased numbers of CD3−CD56+ NK and CD3+CD56+ NKT-like cells were observed in COPD patients compared to HNS.
The frequencies of inducible IFN-γ-secreting NK and NKT-like cells were less in COPD patients.
The frequencies of CD158a and CD158b on NK cells and CD158b on NKT-like cells were greater.
The frequency of CD158b+ NK cells was negatively correlated with FEV1% prediction and FEV1/FVC.
Our data indicate that COPD patients have immune dysfunction, and higher frequencies of inhibitory NK cells and NKT-like cells may participate in the pathogenesis of COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Ying& Li, Xiaodan& Wang, Man& Zou, Qi& Zhao, Shasha& Sun, Bowen…[et al.]. 2013. Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493371
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Ying…[et al.]. Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-493371
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Ying& Li, Xiaodan& Wang, Man& Zou, Qi& Zhao, Shasha& Sun, Bowen…[et al.]. Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493371
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493371
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر