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The Effects of Acute Stress-Induced Sleep Disturbance on Acoustic Trauma-Induced Tinnitus in Rats
المؤلفون المشاركون
Chien, Yi-Ting
Zheng, Yiwen
Stiles, Lucy
Darlington, Cynthia L.
Smith, Paul F.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Chronic tinnitus is a debilitating condition and often accompanied by anxiety, depression, and sleep disturbance.
It has been suggested that sleep disturbance, such as insomnia, may be a risk factor/predictor for tinnitus-related distress and the two conditions may share common neurobiological mechanisms.
This study investigated whether acute stress-induced sleep disturbance could increase the susceptibility to acoustic trauma-induced tinnitus in rats.
The animals were exposed to unilateral acoustic trauma 24 h before sleep disturbance being induced using the cage exchange method.
Tinnitus perception was assessed behaviourally using a conditioned lick suppression paradigm 3 weeks after the acoustic trauma.
Changes in the orexin system in the hypothalamus, which plays an important role in maintaining long-lasting arousal, were also examined using immunohistochemistry.
Cage exchange resulted in a significant reduction in the number of sleep episodes and acoustic trauma-induced tinnitus with acoustic features similar to a 32 kHz tone at 100 dB.
However, sleep disturbance did not exacerbate the perception of tinnitus in rats.
Neither tinnitus alone nor tinnitus plus sleep disturbance altered the number of orexin-expressing neurons.
The results suggest that acute sleep disturbance does not cause long-term changes in the number of orexin neurons and does not change the perception of tinnitus induced by acoustic trauma in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Yiwen& Stiles, Lucy& Chien, Yi-Ting& Darlington, Cynthia L.& Smith, Paul F.. 2014. The Effects of Acute Stress-Induced Sleep Disturbance on Acoustic Trauma-Induced Tinnitus in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-493521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Yiwen…[et al.]. The Effects of Acute Stress-Induced Sleep Disturbance on Acoustic Trauma-Induced Tinnitus in Rats. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-493521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Yiwen& Stiles, Lucy& Chien, Yi-Ting& Darlington, Cynthia L.& Smith, Paul F.. The Effects of Acute Stress-Induced Sleep Disturbance on Acoustic Trauma-Induced Tinnitus in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-493521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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