How the Virus Outsmarts the Host : Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance

المؤلفون المشاركون

Wang, Rui
Hong, Manqing
Natarajan, Kannan
Margulies, David H.
Revilleza, Maria Jamela
Mans, Janet

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-06-30

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Natural killer (NK) cells provide an initial host immune response to infection by many viral pathogens.

Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral fitness.

One mechanism employed by members of the β-herpesvirus family, which includes the cytomegaloviruses, is to modulate the expression of cell surface ligands recognized by NK cell activation molecules.

A novel set of cytomegalovirus (CMV) genes, exemplified by the mouse m145 family, encode molecules that have structural and functional features similar to those of host major histocompatibility-encoded (MHC) class I molecules, some of which are known to contribute to immune evasion.

In this review, we explore the function, structure, and evolution of MHC-I-like molecules of the CMVs and speculate on the dynamic development of novel immunoevasive functions based on the MHC-I protein fold.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Revilleza, Maria Jamela& Wang, Rui& Mans, Janet& Hong, Manqing& Natarajan, Kannan& Margulies, David H.. 2011. How the Virus Outsmarts the Host : Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493560

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Revilleza, Maria Jamela…[et al.]. How the Virus Outsmarts the Host : Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-493560

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Revilleza, Maria Jamela& Wang, Rui& Mans, Janet& Hong, Manqing& Natarajan, Kannan& Margulies, David H.. How the Virus Outsmarts the Host : Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493560

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-493560