Impaired Skeletal Muscle Repair after Ischemia-Reperfusion Injury in Mice

المؤلفون المشاركون

Agbulut, O.
Ferry, A.
Vignaud, A.
Hourde, C.
Medja, F.
Butler-Browne, G.

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-05-09

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Ischemia/reperfusion (IR) injury can induce skeletal muscle fibre death and subsequent regeneration.

By 14 days, absolute and specific maximal forces and fatigue resistance in ischemic/reperfused soleus muscles were still reduced (−89%, −81%, and −75%, resp.) as compared to control muscles (P<.05).

The decrease of these parameters in ischemic/reperfused muscle was much greater than that of myotoxic injured muscles (−12%, −11%, and −19%; P<.05).

In addition, at 14 days ischemic/reperfused muscle structure was still abnormal, showing small muscle fibres expressing neonatal myosin heavy chain and large necrotic muscle fibres that were not observed in myotoxin treated muscles.

By 56 days, in contrast to myotoxin treated muscles, specific maximal force and muscle weight of the ischemic/reperfused muscles did not fully recover (P<.05).

This differential recovery between ischemic/reperfused and myotoxin treated muscles was not related to the differences in the initial cell death, loss of satellite cells after injury, expression of growth factors (IGF1, IGF2..), or capillary density in regenerating muscles.

In conclusion, our results demonstrate that IR injury in mice induces long term detrimental effects in skeletal muscles and that the recovery following IR injury was delayed for yet unknown reasons as compared to myotoxic injury.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Vignaud, A.& Hourde, C.& Medja, F.& Agbulut, O.& Butler-Browne, G.& Ferry, A.. 2010. Impaired Skeletal Muscle Repair after Ischemia-Reperfusion Injury in Mice. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-493586

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Vignaud, A.…[et al.]. Impaired Skeletal Muscle Repair after Ischemia-Reperfusion Injury in Mice. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-493586

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Vignaud, A.& Hourde, C.& Medja, F.& Agbulut, O.& Butler-Browne, G.& Ferry, A.. Impaired Skeletal Muscle Repair after Ischemia-Reperfusion Injury in Mice. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-493586

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-493586