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Long Pentraxin 3 : Experimental and Clinical Relevance in Cardiovascular Diseases
المؤلفون المشاركون
Catapano, Alberico Luigi
Baragetti, Andrea
Bonacina, Fabrizia
Norata, Giuseppe Danilo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and belongs, together with the C-reactive protein (CRP) and other acute phase proteins, to the pentraxins' superfamily: soluble, multifunctional, pattern recognition proteins.
Pentraxins share a common C-terminal pentraxin domain, which in the case of PTX3 is coupled to an unrelated long N-terminal domain.
PTX3 in humans, like CRP, correlates with surrogate markers of atherosclerosis and is independently associated with the risk of developing vascular events.
Studies addressing the potential physiopathological role of CRP in the cardiovascular system were so far inconclusive and have been limited by the fact that the sequence and regulation have not been conserved during evolution between mouse and man.
On the contrary, the conservation of sequence, gene organization, and regulation of PTX3 supports the translation of animal model findings in humans.
While PTX3 deficiency is associated with increased inflammation, cardiac damage, and atherosclerosis, the overexpression limits carotid restenosis after angioplasty.
These observations point to a cardiovascular protective effect of PTX3 potentially associated with the ability of tuning inflammation and favor the hypothesis that the increased levels of PTX3 in subjects with cardiovascular diseases may reflect a protective physiological mechanism, which correlates with the immunoinflammatory response observed in several cardiovascular disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bonacina, Fabrizia& Baragetti, Andrea& Catapano, Alberico Luigi& Norata, Giuseppe Danilo. 2013. Long Pentraxin 3 : Experimental and Clinical Relevance in Cardiovascular Diseases. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bonacina, Fabrizia…[et al.]. Long Pentraxin 3 : Experimental and Clinical Relevance in Cardiovascular Diseases. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-493605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bonacina, Fabrizia& Baragetti, Andrea& Catapano, Alberico Luigi& Norata, Giuseppe Danilo. Long Pentraxin 3 : Experimental and Clinical Relevance in Cardiovascular Diseases. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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