Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain : Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model
المؤلفون المشاركون
Selip, D. B.
Chang, M.
Boll, G.
Jantzie, L. L.
Jackson, M. C.
Murphy, A.
Fitzgerald, E. C.
Jensen, F. E.
المصدر
Neurology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Models of premature brain injury have largely focused on the white matter injury thought to underlie periventricular leukomalacia (PVL).
However, with increased survival of very low birth weight infants, injury patterns involving grey matter are now recognized.
We aimed to determine how grey matter lesions relate to hypoxic-ischemic- (HI) mediated white matter injury by modifying our rat model of PVL.
Following HI, microglial infiltration, astrocytosis, and neuronal and axonal degeneration increased in a region-specific manner dependent on the severity of myelin loss in pericallosal white matter.
The spectrum of injury ranged from mild, where diffuse white matter abnormalities were dominant and were associated with mild axonal injury and local microglial activation, to severe HI injury characterized by focal MBP loss, widespread neuronal degeneration, axonal damage, and gliosis throughout the neocortex, caudate putamen, and thalamus.
In sum, selective regional white matter loss occurs in the preterm rat concomitantly with a clinically relevant spectrum of grey matter injury.
These data demonstrate an interspecies similarity of brain injury patterns and further substantiates the reliable use of this model for the study of preterm brain injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Selip, D. B.& Jantzie, L. L.& Chang, M.& Jackson, M. C.& Fitzgerald, E. C.& Boll, G.…[et al.]. 2012. Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain : Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model. Neurology Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-493616
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Selip, D. B.…[et al.]. Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain : Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model. Neurology Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-493616
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Selip, D. B.& Jantzie, L. L.& Chang, M.& Jackson, M. C.& Fitzgerald, E. C.& Boll, G.…[et al.]. Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain : Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-493616
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493616
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر