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Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma
المؤلفون المشاركون
Umar, Anwar
Moore, Nicholas
Amat, Nurmuhammat
Halmurati, Upur
Abdureyim, Sajida
Berke, Benedicte
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Ravan Napas (RN) is a traditional formula used to treat pulmonary symptoms and diseases such as coughing, breathing difficulty, and asthma in traditional Uighur medicine.
The purpose of this study was to investigate the anti-inflammatory, and immuno-modulatory activity of RN in a well-characterized animal model of allergic asthma.
Rats were sensitized with intraperitoneal (ip) ovalbumin (OVA) and alum, and then challenged with OVA aerosols.
The asthma model rats were treated with RN; saline- and dexamethasone- (DXM-) treated rats served as normal and model controls.
The bronchoalveolar lavage fluid (BALF) cellular differential and the concentrations of sICAM-1, IL-4, IL-5, TNF-α, INF-γ, and IgE in serum were measured.
Lung sections underwent histological analysis.
The immunohistochemistry S-P method was used to measure the expression of ICAM-1 and HO-1 in the lung.
RN significantly reduced the number of inflammatory cells in BALF and lung tissues, decreased sICAM-1, IL-4, IL-5, TNF-α, and IgE in serum, and increased serum INF-γ.
There was a marked suppression of ICAM-1 and HO-1 expression in the lung.
Our results suggest that RN may have an anti-inflammatory and immuneregulatory effect on allergic bronchial asthma by modulating the balance between Th1/Th2 cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdureyim, Sajida& Amat, Nurmuhammat& Umar, Anwar& Halmurati, Upur& Berke, Benedicte& Moore, Nicholas. 2010. Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdureyim, Sajida…[et al.]. Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-493703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdureyim, Sajida& Amat, Nurmuhammat& Umar, Anwar& Halmurati, Upur& Berke, Benedicte& Moore, Nicholas. Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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