Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures
المؤلفون المشاركون
Utkilen, Hans
Duale, Nur
Brunborg, Gunnar
Hofer, Tim
Myhre, Oddvar
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-17
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
A dysregulated metal homeostasis is associated with both Alzheimer’s (AD) and Parkinson’s (PD) diseases; AD patients have decreased cortex and elevated serum copper levels along with extracellular amyloid-beta plaques containing copper, iron, and zinc.
For AD, a putative hepcidin-mediated lowering of cortex copper mechanism is suggested.
An age-related mild chronic inflammation and/or elevated intracellular iron can trigger hepcidin production followed by its binding to ferroportin which is the only neuronal iron exporter, thereby subjecting it to lysosomal degradation.
Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes.
Using in silico gene expression analyses, we here show significantly decreased expression of copper-dependent enzymes in AD brain and metallothioneins were upregulated in both diseases.
Although few AD exposure risk factors are known, AD-related tauopathies can result from cyanobacterial microcystin and β-methylamino-L-alanine (BMAA) intake.
Several environmental exposures may represent risk factors for PD; for this disease neurodegeneration is likely to involve mitochondrial dysfunction, microglial activation, and neuroinflammation.
Administration of metal chelators and anti-inflammatory agents could affect disease outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Myhre, Oddvar& Utkilen, Hans& Duale, Nur& Brunborg, Gunnar& Hofer, Tim. 2013. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Myhre, Oddvar…[et al.]. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-493802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Myhre, Oddvar& Utkilen, Hans& Duale, Nur& Brunborg, Gunnar& Hofer, Tim. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر