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Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures
Joint Authors
Utkilen, Hans
Duale, Nur
Brunborg, Gunnar
Hofer, Tim
Myhre, Oddvar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A dysregulated metal homeostasis is associated with both Alzheimer’s (AD) and Parkinson’s (PD) diseases; AD patients have decreased cortex and elevated serum copper levels along with extracellular amyloid-beta plaques containing copper, iron, and zinc.
For AD, a putative hepcidin-mediated lowering of cortex copper mechanism is suggested.
An age-related mild chronic inflammation and/or elevated intracellular iron can trigger hepcidin production followed by its binding to ferroportin which is the only neuronal iron exporter, thereby subjecting it to lysosomal degradation.
Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes.
Using in silico gene expression analyses, we here show significantly decreased expression of copper-dependent enzymes in AD brain and metallothioneins were upregulated in both diseases.
Although few AD exposure risk factors are known, AD-related tauopathies can result from cyanobacterial microcystin and β-methylamino-L-alanine (BMAA) intake.
Several environmental exposures may represent risk factors for PD; for this disease neurodegeneration is likely to involve mitochondrial dysfunction, microglial activation, and neuroinflammation.
Administration of metal chelators and anti-inflammatory agents could affect disease outcomes.
American Psychological Association (APA)
Myhre, Oddvar& Utkilen, Hans& Duale, Nur& Brunborg, Gunnar& Hofer, Tim. 2013. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493802
Modern Language Association (MLA)
Myhre, Oddvar…[et al.]. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-493802
American Medical Association (AMA)
Myhre, Oddvar& Utkilen, Hans& Duale, Nur& Brunborg, Gunnar& Hofer, Tim. Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases : Possible Impact of Environmental Exposures. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493802