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C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour : A Unique Model to Study C-Kit Driven Human Malignancies
المؤلفون المشاركون
Marech, Ilaria
Zizzo, Nicola
Gadaleta, Claudia
Patruno, Rosa
Nardulli, Patrizia
Gadaleta, Cosmo Damiano
Ribatti, Domenico
Introna, Marcello
Capriuolo, Gennaro
Ranieri, Girolamo
Ammendola, Michele
Rubini, Rosa Angela
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Canine cutaneous mast cell tumour (CMCT) is a c-Kit driven tumour sharing similar c-Kit aberrations found in human gastrointestinal stromal tumour.
CMCT is classified into three forms: well- (G1), intermediately (G2) (more benign diseases), and poorly (G3) differentiated (malignant) forms.
We assess a correlation between c-Kit status, grading, and angiogenesis in CMCTs to explore their potential significance in humans.
C-Kit receptor (c-KitR) expression, microvascular density (MVD), and mast cell granulated and degranulated status density (MCGD and MCDD, resp.) were analyzed in 97 CMCTs, by means of histochemistry, immunohistochemistry double staining, and image analysis system.
Data showed that predominantly diffuse cytoplasmic- and predominantly focal paranuclear- (Golgi-like) c-Kit protein (PDC-c-Kit and PFP-c-Kit, resp.) expression correlate with high MVD, G3 histopathological grade, and MCDD.
Moreover, predominant cell membrane-c-KitR (PCM-c-KitR) expression status correlates with low MVD, G1-G2 histopathological grade, and MCGD.
These findings underline the key role of c-Kit in the biopathology of canine MCTs, indicating a link between aberrant c-Kit expression, increased angiogenesis, and higher histopathological grade.
CMCT seems to be a model to study contributions of c-Kit activated MCs in tumour angiogenesis and to evaluate the inhibition of MCs activation by means of c-Kit tyrosine kinase inhibitors, currently translated in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patruno, Rosa& Marech, Ilaria& Zizzo, Nicola& Ammendola, Michele& Nardulli, Patrizia& Gadaleta, Claudia…[et al.]. 2014. C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour : A Unique Model to Study C-Kit Driven Human Malignancies. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-494082
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patruno, Rosa…[et al.]. C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour : A Unique Model to Study C-Kit Driven Human Malignancies. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-494082
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patruno, Rosa& Marech, Ilaria& Zizzo, Nicola& Ammendola, Michele& Nardulli, Patrizia& Gadaleta, Claudia…[et al.]. C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour : A Unique Model to Study C-Kit Driven Human Malignancies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-494082
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494082
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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