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Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3 : Potential Clinical Implications
المؤلفون المشاركون
Peri, Giuseppe
Morandi, Fabio
Pistorio, Angela
Prigione, Ignazia
Carleo, Anna Maria
Mantovani, Alberto
Lerzo, Franco
Pistoia, Vito
Doni, Andrea
Bocca, Paola
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome.
Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation.
Twenty-nine children undergoing open heart surgery were enrolled in the study.
Fourteen received dexamethasone (1st dose 1.5 mg/Kg i.v.
or i.m.
the evening before surgery; 2nd dose 1.5 mg/kg i.v.
before starting bypass) and fifteen children served as control.
Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times.
PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (−D) subjects, but were significantly higher in +D than −D patients.
CRP levels significantly increased both in +D and −D patients in the postoperative days, with values significantly higher in −D than +D patients.
Fibrinogen and PTT values were significantly higher in −D than +D patients in the 1st postoperative day.
IL-1RII plasma levels increased in the postoperative period in both groups.
Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lerzo, Franco& Peri, Giuseppe& Doni, Andrea& Bocca, Paola& Morandi, Fabio& Pistorio, Angela…[et al.]. 2011. Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3 : Potential Clinical Implications. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lerzo, Franco…[et al.]. Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3 : Potential Clinical Implications. Clinical and Developmental Immunology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lerzo, Franco& Peri, Giuseppe& Doni, Andrea& Bocca, Paola& Morandi, Fabio& Pistorio, Angela…[et al.]. Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3 : Potential Clinical Implications. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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