Chinese Herbal Medicine for Acute Mountain Sickness : A Systematic Review of Randomized Controlled Trials

الملخص EN

Objectives.

We aimed to assess the current clinical evidence of Chinese herbal medicine for AMS.

Methods.

Seven electronic databases were searched until January 2013.

We included randomized clinical trials testing Chinese herbal medicine against placebo, no drugs, Western drugs, or a combination of routine treatment drugs against routine treatment drugs.

Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards.

Results.

Nine randomized trials were included.

The methodological quality of the included trials was evaluated as low.

Two trials compared prescriptions of Chinese formula used alone with Western drugs.

A meta-analysis showed a beneficial effect in decreasing the score of AMS (MD: −2.23 [−3.98, −0.49], P=0.01).

Only one trial compared prescriptions of Chinese formula used alone with no drugs.

A meta-analysis showed a significant beneficial effect in decreasing the score of AMS (MD: −6.00 [−6.45, −5.55], P<0.00001).

Four trials compared Chinese formula used alone with placebo.

A meta-analysis also showed a significant beneficial effect in decreasing the score of AMS (MD: −1.10 [−1.64, −0.55], P<0.0001).

Two trials compared the combination of Chinese formula plus routine treatment drugs with routine treatment drugs.

A meta-analysis showed a beneficial effect in decreasing the score of AMS (MD: −5.99 [−11.11, −0.86], P=0.02).

Conclusions.

No firm conclusion on the effectiveness and safety of Chinese herbal medicine for AMS can be made.

More rigorous high-quality trials are required to generate a high level of evidence and to confirm the results.