Successful Treatment of Methimazole-Induced Severe Aplastic Anemia by Granulocyte Colony-Stimulating Factor, Methylprednisolone, and Cyclosporin

الملخص EN

A 52-year-old Japanese woman was examined because of general malaise, weight loss and a lump in her left breast.

She was diagnosed with cancer of the left breast and Graves' disease, and was administered methimazole (MMI).

A left mastectomy was performed for the breast cancer.

She presented with a high fever and peripheral blood examination revealed a severe pancytopenia.

She was diagnosed with severe aplastic anemia, and administered G-CSF, however, the treatment was unsuccessful.

Thus, oral methyprednisolone and cyclosporin were added.

There was a remarkable improvement in the peripheral blood count.