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Immunomodulatory Role of Ocimum gratissimum and Ascorbic Acid against Nicotine-Induced Murine Peritoneal Macrophages In Vitro
المؤلفون المشاركون
Chakraborty, Subhankari Prasad
Roy, Somenath
Kar Mahapatra, Santanu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The aim of this present study was to evaluate the immune functions and immune responses in nicotine-induced (10 mM) macrophages and concurrently establish the immunomodulatory role of aqueous extract of Ocimum gratissimum (Ae-Og) and ascorbic acid.
In this study, nitrite generations and some phenotype functions by macrophages were studied.
Beside that, release of Th1 cytokines (TNF-α, IL-12) and Th2 cytokines (IL-10, TGF-β) was measured by ELISA, and the expression of these cytokines at mRNA level was analyzed by real-time PCR.
Ae-Og, at a dose of 10 μg/mL, significantly reduced the nicotine-induced NO generation and iNOSII expression.
Similar kinds of response were observed with supplementation of ascorbic acid (0.01 mM).
The administration of Ae-Og and ascorbic acid increased the decreased adherence, chemotaxis, phagocytosis, and intracellular killing of bacteria in nicotine-treated macrophages.
Ae-Og and ascorbic acid were found to protect the murine peritoneal macrophages through downregulation of Th1 cytokines in nicotine-treated macrophages with concurrent activation of Th2 responses.
These findings strongly enhanced our understanding of the molecular mechanism leading to nicotine-induced suppression of immune functions and provide additional rationale for application of anti-inflammatory therapeutic approaches by O.
gratissimum and ascorbic acid for different inflammatory disease prevention and treatment during nicotine toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kar Mahapatra, Santanu& Chakraborty, Subhankari Prasad& Roy, Somenath. 2011. Immunomodulatory Role of Ocimum gratissimum and Ascorbic Acid against Nicotine-Induced Murine Peritoneal Macrophages In Vitro. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kar Mahapatra, Santanu…[et al.]. Immunomodulatory Role of Ocimum gratissimum and Ascorbic Acid against Nicotine-Induced Murine Peritoneal Macrophages In Vitro. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-494396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kar Mahapatra, Santanu& Chakraborty, Subhankari Prasad& Roy, Somenath. Immunomodulatory Role of Ocimum gratissimum and Ascorbic Acid against Nicotine-Induced Murine Peritoneal Macrophages In Vitro. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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