The Missing Heritability in T1D and Potential New Targets for Prevention
المؤلفون المشاركون
Pierce, Brian G.
Blankenhorn, Elizabeth P.
Weng, Zhiping
Eberwine, Ryan
Noble, Janelle A.
Habib, Michael
Mordes, John P.
Shulha, Hennady P.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Type 1 diabetes (T1D) is a T cell-mediated disease.
It is strongly associated with susceptibility haplotypes within the major histocompatibility complex, but this association accounts for an estimated 50% of susceptibility.
Other studies have identified as many as 50 additional susceptibility loci, but the effect of most is very modest (odds ratio (OR) <1.5).
What accounts for the “missing heritability” is unknown and is often attributed to environmental factors.
Here we review new data on the cognate ligand of MHC molecules, the T cell receptor (TCR).
In rats, we found that one allele of a TCR variable gene, Vβ13A, is strongly associated with T1D (OR >5) and that deletion of Vβ13+ T cells prevents diabetes.
A role for the TCR is also suspected in NOD mice, but TCR regions have not been associated with human T1D.
To investigate this disparity, we tested the hypothesis in silico that previous studies of human T1D genetics were underpowered to detect MHC-contingent TCR susceptibility.
We show that stratifying by MHC markedly increases statistical power to detect potential TCR susceptibility alleles.
We suggest that the TCR regions are viable candidates for T1D susceptibility genes, could account for “missing heritability,” and could be targets for prevention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pierce, Brian G.& Eberwine, Ryan& Noble, Janelle A.& Habib, Michael& Shulha, Hennady P.& Weng, Zhiping…[et al.]. 2013. The Missing Heritability in T1D and Potential New Targets for Prevention. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pierce, Brian G.…[et al.]. The Missing Heritability in T1D and Potential New Targets for Prevention. Journal of Diabetes Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-494689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pierce, Brian G.& Eberwine, Ryan& Noble, Janelle A.& Habib, Michael& Shulha, Hennady P.& Weng, Zhiping…[et al.]. The Missing Heritability in T1D and Potential New Targets for Prevention. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر