Optimizing Molecular-Targeted Therapies in Ovarian Cancer : The Renewed Surge of Interest in Ovarian Cancer Biomarkers and Cell Signaling Pathways
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-06
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The hallmarks of ovarian cancer encompass the development of resistance, disease recurrence and poor prognosis.
Ovarian cancer cells express gene signatures which pose significant challenges for cancer drug development, therapeutics, prevention and management.
Despite enhancements in contemporary tumor debulking surgery, tentative combination regimens and abdominal radiation which can achieve beneficial response rates, the majority of ovarian cancer patients not only experience adverse effects, but also eventually relapse.
Therefore, additional therapeutic possibilities need to be explored to minimize adverse events and prolong progression-free and overall response rates in ovarian cancer patients.
Currently, a revival in cancer drug discovery is devoted to identifying diagnostic and prognostic ovarian cancer biomarkers.
However, the sensitivity and reliability of such biomarkers may be complicated by mutations in the BRCA1 or BRCA2 genes, diverse genetic risk factors, unidentified initiation and progression elements, molecular tumor heterogeneity and disease staging.
There is thus a dire need to expand existing ovarian cancer therapies with broad-spectrum and individualized molecular targeted approaches.
The aim of this review is to profile recent developments in our understanding of the interrelationships among selected ovarian tumor biomarkers, heterogeneous expression signatures and related molecular signal transduction pathways, and their translation into more efficacious targeted treatment rationales.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hiss, Donavon. 2012. Optimizing Molecular-Targeted Therapies in Ovarian Cancer : The Renewed Surge of Interest in Ovarian Cancer Biomarkers and Cell Signaling Pathways. Journal of Oncology،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-494716
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hiss, Donavon. Optimizing Molecular-Targeted Therapies in Ovarian Cancer : The Renewed Surge of Interest in Ovarian Cancer Biomarkers and Cell Signaling Pathways. Journal of Oncology No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-494716
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hiss, Donavon. Optimizing Molecular-Targeted Therapies in Ovarian Cancer : The Renewed Surge of Interest in Ovarian Cancer Biomarkers and Cell Signaling Pathways. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-494716
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494716
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر