IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes
المؤلفون المشاركون
Kawakita, Akiko
Murai, Hiroki
Yasutomi, Motoko
Okazaki, Shintaro
Hayashi, Hisako
Ohshima, Yusei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Interleukin-33 appears to play important roles in the induction of allergic airway inflammation.
However, whether IL-33 is involved in airway remodeling remains unclear.
Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions.
Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33.
IL-33 enhanced cell proliferation, α-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-β1 production.
Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33.
Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production.
Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33.
These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation.
IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hayashi, Hisako& Kawakita, Akiko& Okazaki, Shintaro& Murai, Hiroki& Yasutomi, Motoko& Ohshima, Yusei. 2014. IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-494789
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hayashi, Hisako…[et al.]. IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-494789
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hayashi, Hisako& Kawakita, Akiko& Okazaki, Shintaro& Murai, Hiroki& Yasutomi, Motoko& Ohshima, Yusei. IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-494789
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494789
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر