Efficacy and Tolerability of Peginterferon α-2a and Peginterferon α-2b, Both plus Ribavirin, for Chronic Hepatitis C : A Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Yang, Zongguo
Chen, Xiaorong
Yang, Lei
Zhuang, Liping
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
The efficacy and tolerability of peginterferon α-2a and peginterferon α-2b in chronic hepatitis C (CHC) patients remain controversial.
Methods.
PubMed, Ovid, and Cochrane libraries were electronically searched until August 30, 2012.
Studies that met the inclusion criteria were systematically evaluated by two reviewers independently.
Results.
The overall sustained virologic response (SVR) rate of the peginterferon α-2a group was significantly higher than that of the peginterferon α-2b group (46.7% versus 42.4%, P value = 0.01).
The same tendency was observed for naïve, genotype 1/4, and genotype 2/3 patients.
The early virologic response (EVR) and end-of-treatment response (ETR) rates were significantly higher in the peginterferon α-2a group than in the peginterferon α-2b group (56.1% versus 49.8%, P<0.0001; 67.9% versus 56.6%, P<0.00001, resp.).
Peginterferon α-2a had a significantly lower discontinuation rate than peginterferon α-2b (27.9% versus 33.9%, P<0.0001) in naïve patients.
In both naïve CHC and hepatitis C virus genotype 1 patients, peginterferon α-2a had a higher relapse rate than peginterferon α-2b.
Conclusions.
Peginterferon α-2a has superior efficacy with higher EVR, ETR, and SVR than peginterferon α-2b for CHC patients, both plus ribavirin.
Peginterferon α-2a might obtain a similar or even lower discontinuation rate than peginterferon α-2b.
However, peginterferon α-2a had a higher relapse rate than peginterferon α-2b.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Zongguo& Zhuang, Liping& Yang, Lei& Chen, Xiaorong. 2013. Efficacy and Tolerability of Peginterferon α-2a and Peginterferon α-2b, Both plus Ribavirin, for Chronic Hepatitis C : A Meta-Analysis of Randomized Controlled Trials. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494816
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Zongguo…[et al.]. Efficacy and Tolerability of Peginterferon α-2a and Peginterferon α-2b, Both plus Ribavirin, for Chronic Hepatitis C : A Meta-Analysis of Randomized Controlled Trials. Gastroenterology Research and Practice No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-494816
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Zongguo& Zhuang, Liping& Yang, Lei& Chen, Xiaorong. Efficacy and Tolerability of Peginterferon α-2a and Peginterferon α-2b, Both plus Ribavirin, for Chronic Hepatitis C : A Meta-Analysis of Randomized Controlled Trials. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494816
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494816
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر