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Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer
المؤلفون المشاركون
Obayashi, Yukihiko
Wakatsuki, Akihiko
Iwasaki, Keita
Zhuo, Lisheng
Kimata, Koji
Itano, Naoki
Kanyama, Kouhei
Yabushita, Hiromitsu
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated.
The relationship of metalloproteinase (MMP) and its inhibitor (TIMP) with HA and the SHAP-HA complex was also examined.
The expression of HAS1 was related to the depth of myometrial invasion and lymph-vascular space involvement.
The serum levels of HA, SHAP-HA complex, MMP-9, and TIMP-1 were increased in related with the depth of myometrial invasion, histological grade and lymph-vascular space involvement.
They were also higher in the HAS1-positive group compared to -negative group.
The serum concentrations of HA and SHAP-HA complex had a significant correlation with the MMP-9 and TIMP-1.
The patients with elevated SHAP-HA complex had the shorter disease-free survival.
The multivariate analysis revealed that the SHAP-HA complex was the independent variable for disease-free survival of endometrial cancer patients.
In conclusion, the elevation of serum SHAP-HA complex depended on the HAS1 expression and the SHAP-HA complex is a useful marker to predict disease recurrence in endometrial cancer patients.
The SHAP-HA complex may promote the lymph-vascular space involvement and the synthesis and activation of MMP-9 and TIMP-1 in the progression of endometrial cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yabushita, Hiromitsu& Iwasaki, Keita& Kanyama, Kouhei& Obayashi, Yukihiko& Zhuo, Lisheng& Itano, Naoki…[et al.]. 2011. Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer. Obstetrics and Gynecology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yabushita, Hiromitsu…[et al.]. Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer. Obstetrics and Gynecology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-494826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yabushita, Hiromitsu& Iwasaki, Keita& Kanyama, Kouhei& Obayashi, Yukihiko& Zhuo, Lisheng& Itano, Naoki…[et al.]. Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer. Obstetrics and Gynecology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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