Central Role of the EGF Receptor in Neurometabolic Aging
المؤلفون المشاركون
Siddiqui, Sana
Fang, Meng
Maudsley, Stuart
Ni, Bin
Lu, Daoyuan
Martin, Bronwen
المصدر
International Journal of Endocrinology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-17
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
A strong connection between neuronal and metabolic health has been revealed in recent years.
It appears that both normal and pathophysiological aging, as well as neurodegenerative disorders, are all profoundly influenced by this “neurometabolic” interface, that is, communication between the brain and metabolic organs.
An important aspect of this “neurometabolic” axis that needs to be investigated involves an elucidation of molecular factors that knit these two functional signaling domains, neuronal and metabolic, together.
This paper attempts to identify and discuss a potential keystone signaling factor in this “neurometabolic” axis, that is, the epidermal growth factor receptor (EGFR).
The EGFR has been previously demonstrated to act as a signaling nexus for many ligand signaling modalities and cellular stressors, for example, radiation and oxidative radicals, linked to aging and degeneration.
The EGFR is expressed in a wide variety of cells/tissues that pertain to the coordinated regulation of neurometabolic activity.
EGFR signaling has been highlighted directly or indirectly in a spectrum of neurometabolic conditions, for example, metabolic syndrome, diabetes, Alzheimer’s disease, cancer, and cardiorespiratory function.
Understanding the positioning of the EGFR within the neurometabolic domain will enhance our appreciation of the ability of this receptor system to underpin highly complex physiological paradigms such as aging and neurodegeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siddiqui, Sana& Fang, Meng& Ni, Bin& Lu, Daoyuan& Martin, Bronwen& Maudsley, Stuart. 2012. Central Role of the EGF Receptor in Neurometabolic Aging. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-494852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siddiqui, Sana…[et al.]. Central Role of the EGF Receptor in Neurometabolic Aging. International Journal of Endocrinology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-494852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siddiqui, Sana& Fang, Meng& Ni, Bin& Lu, Daoyuan& Martin, Bronwen& Maudsley, Stuart. Central Role of the EGF Receptor in Neurometabolic Aging. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-494852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر