Redox Mechanisms of AVS022, an Oriental Polyherbal Formula, and Its Component Herbs in Protection against Induction of Matrix Metalloproteinase-1 in UVA-Irradiated Keratinocyte HaCaT Cells
المؤلفون المشاركون
Laohapand, Tawee
Pluemsamran, Thanyawan
Phadungrakwittaya, Rattana
Akarasereenont, Pravit
Tripatara, Pinpat
Panich, Uraiwan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ayurved Siriraj HaRak (AVS022) formula has been used for topical remedy of dermatologic disorders.
Oxidative stress induced by ultraviolet (UV) A irradiation could be implicated in photoaged skin through triggering matrix metalloproteinase-1 (MMP-1).
We, therefore, explored the antioxidant mechanisms by which AVS022 formulation and its individual components protected against UVA-dependent MMP-1 upregulation in keratinocyte HaCaT cells.
TLC analysis revealed the presence of multiple phenolics including gallic acid (GA) in the AVS022 extracts.
We demonstrated that pretreatment with the whole formula and individual herbal components except T.
triandra protected against increased MMP-1 activity in irradiated HaCaT cells.
Moreover, all herbal extracts and GA, used as the reference compound, were able to reverse cytotoxicity, oxidant production, glutathione (GSH) loss, and inactivation of catalase and glutathione peroxidase (GPx).
F.
racemosa was observed to yield the strongest abilities to abolish UVA-mediated induction of MMP-1 and impairment of antioxidant defenses including GSH and catalase.
Our observations suggest that upregulation of endogenous antioxidants could be the mechanisms by which AVS022 and its herbal components suppressed UVA-stimulated MMP-1 in HaCaT cells.
In addition, pharmacological actions of AVS022 formula may be attributed to the antioxidant potential of its components, in particular F.
racemosa, and several phenolics including GA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pluemsamran, Thanyawan& Tripatara, Pinpat& Phadungrakwittaya, Rattana& Akarasereenont, Pravit& Laohapand, Tawee& Panich, Uraiwan. 2013. Redox Mechanisms of AVS022, an Oriental Polyherbal Formula, and Its Component Herbs in Protection against Induction of Matrix Metalloproteinase-1 in UVA-Irradiated Keratinocyte HaCaT Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pluemsamran, Thanyawan…[et al.]. Redox Mechanisms of AVS022, an Oriental Polyherbal Formula, and Its Component Herbs in Protection against Induction of Matrix Metalloproteinase-1 in UVA-Irradiated Keratinocyte HaCaT Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-494859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pluemsamran, Thanyawan& Tripatara, Pinpat& Phadungrakwittaya, Rattana& Akarasereenont, Pravit& Laohapand, Tawee& Panich, Uraiwan. Redox Mechanisms of AVS022, an Oriental Polyherbal Formula, and Its Component Herbs in Protection against Induction of Matrix Metalloproteinase-1 in UVA-Irradiated Keratinocyte HaCaT Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر