Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro

المؤلفون المشاركون

Picot, Carene M. N.
Mahmudi, M. Fawzi
Subratty, A. Hussein

المصدر

Advances in Pharmacological Sciences

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-03-02

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

علم الصيدلة

الملخص EN

Five traditionally used antidiabetic native medicinal plants of Mauritius, namely, Stillingia lineata (SL), Faujasiopsis flexuosa (FF), Erythroxylum laurifolium (EL), Elaeodendron orientale (EO), and Antidesma madagascariensis (AM), were studied for possible α-amylase and α-glucosidase inhibitory property, glucose entrapment, and amylolysis kinetics in vitro.

Only methanolic extracts of EL, EO, and AM (7472.92±5.99, 1745.58±31.66, and 2222.96±13.69 μg/mL, resp.) were found to significantly (P<0.05) inhibit α-amylase and were comparable to acarbose.

EL, EO, AM, and SL extracts (5000 μg/mL) were found to significantly (P<0.05) inhibit α-glucosidase (between 87.41±3.31 and 96.87±1.37% inhibition).

Enzyme kinetic studies showed an uncompetitive and mixed type of inhibition.

Extracts showed significant (P<0.05) glucose entrapment capacities (8 to 29% glucose diffusion retardation index (GDRI)), with SL being more active (29% GDRI) and showing concentration-dependent activity (29, 26, 21, 14, and 5%, resp.).

Amylolysis kinetic studies showed that methanolic extracts were more potent inhibitors of α-amylase compared to aqueous extracts and possessed glucose entrapment properties.

Our findings tend to provide justification for the hypoglycaemic action of these medicinal plants which has opened novel avenues for the development of new phytopharmaceuticals geared towards diabetes management.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Picot, Carene M. N.& Subratty, A. Hussein& Mahmudi, M. Fawzi. 2014. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological Sciences،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494891

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Picot, Carene M. N.…[et al.]. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological Sciences No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-494891

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Picot, Carene M. N.& Subratty, A. Hussein& Mahmudi, M. Fawzi. Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro. Advances in Pharmacological Sciences. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494891

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-494891