Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases

المؤلفون المشاركون

Masaki, Toshihiro
Matsumura, Kiichiro

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-06-15

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الطب البشري

الملخص EN

Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.

Dystroglycan plays diverse roles in development and homeostasis including basement membrane formation, epithelial morphogenesis, membrane stability, cell polarization, and cell migration.

In this paper, we will focus on biological role of dystroglycan in Schwann cell function, especially myelination.

First, we review the molecular architecture of DGC in Schwann cell abaxonal membrane.

Then, we will review the loss-of-function studies using targeted mutagenesis, which have revealed biological functions of each component of DGC in Schwann cells.

Based on these findings, roles of dystroglycan in Schwann cell function, in myelination in particular, and its implications in diseases will be discussed in detail.

Finally, in view of the fact that understanding the role of dystroglycan in Schwann cells is just beginning, future perspectives will be discussed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Masaki, Toshihiro& Matsumura, Kiichiro. 2010. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-494927

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Masaki, Toshihiro& Matsumura, Kiichiro. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-494927

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Masaki, Toshihiro& Matsumura, Kiichiro. Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-494927

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-494927