Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models : Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts
المؤلفون المشاركون
Ross, Kristie R.
Kelley, Thomas J.
Darrah, Rebecca J.
Lang, LaTresa
Hodges, Craig A.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The simultaneous rise in the prevalence of asthma and obesity has prompted epidemiologic studies that establish obesity as a risk factor for asthma.
The alterations in cell signaling that explain this link are not well understood and warrant investigation so that therapies that target this asthma phenotype can be developed.
We identified a significant increase in expression of the small GTPase RhoA in nasal epithelial cells and tracheal smooth muscle cells from leptin-deficient (ob/ob) mice compared to their wild-type counterparts.
Since RhoA function is dependent on isoprenoid modification, we sought to determine the role of isoprenoid-mediated signaling in regulating the viability and proliferation of human airway smooth muscle cells (ASM) and normal human lung fibroblasts (NHLF).
Inhibiting isoprenoid signaling with mevastatin significantly decreased the viability of ASM and NHLF.
This inhibition was reversed by geranylgeranyl pyrophosphate (GGPP), but not farnesyl pyrophosphate (FPP), suggesting specificity to the Rho GTPases.
Conversely, increasing isoprenoid synthesis significantly increased ASM proliferation and RhoA protein expression.
RhoA expression is inherently increased in airway tissue from ob/ob mice, and obesity-entrained alterations in this pathway may make it a novel therapeutic target for treating airway disease in the obese population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ross, Kristie R.& Darrah, Rebecca J.& Hodges, Craig A.& Lang, LaTresa& Kelley, Thomas J.. 2013. Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models : Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts. Journal of Allergy،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ross, Kristie R.…[et al.]. Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models : Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts. Journal of Allergy No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-494987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ross, Kristie R.& Darrah, Rebecca J.& Hodges, Craig A.& Lang, LaTresa& Kelley, Thomas J.. Increased Expression of RhoA in Epithelium and Smooth Muscle of Obese Mouse Models : Implications for Isoprenoid Control of Airway Smooth Muscle and Fibroblasts. Journal of Allergy. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر