Potential of Peptides as Inhibitors and Mimotopes : Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-10
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Glycoconjugates play various roles in biological processes.
In particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication.
Inhibitors of carbohydrate-protein interactions are potential antiviral drugs.
Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase.
However, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the isolation of natural products.
In addition, the pathogenic capsular polysaccharides of bacteria are carbohydrate antigens, for which a safe and efficacious method of vaccination is required.
Phage-display technology has been improved to enable the identification of peptides that bind to carbohydrate-binding proteins, such as lectins and antibodies, from a large repertoire of peptide sequences.
These peptides are known as “carbohydrate-mimetic peptides (CMPs)” because they mimic carbohydrate structures.
Compared to carbohydrate derivatives, it is easy to prepare mono- and multivalent peptides and then to modify them to create various derivatives.
Such mimetic peptides are available as peptide inhibitors of carbohydrate-protein interactions and peptide mimotopes that are conjugated with adjuvant for vaccination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matsubara, Teruhiko. 2012. Potential of Peptides as Inhibitors and Mimotopes : Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matsubara, Teruhiko. Potential of Peptides as Inhibitors and Mimotopes : Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries. Journal of Nucleic Acids No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-494990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matsubara, Teruhiko. Potential of Peptides as Inhibitors and Mimotopes : Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر