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HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation
المؤلفون المشاركون
Ishige, Ikuo
Eikawa, Shingo
Yamazaki, Chihiro
Kato, Yu
Udono, Heiichiro
Mizukami, Shusaku
Kakimi, Kazuhiro
Kajiwara, Chiaki
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Antigens (Ag) from cancer or virus-infected cells must be internalized by dendritic cells (DCs) to be presented to CD8+ T cells, which eventually differentiate into Ag-specific cytotoxic T lymphocytes (CTLs) that destroy cancer cells and infected cells.
This pathway is termed cross-presentation and is also implicated as an essential step in triggering autoimmune diseases such as Type I diabetes.
Internalized Ag locates within endosomes, followed by translocation through a putative pore structure spanning endosomal membranes into the cytosol, where it is degraded by the proteasome to generate antigen peptides.
During translocation, Ag is believed to be unfolded since the pore size is too narrow to accept native Ag structure.
Here, we show that paraformaldehyde-fixed, structurally inflexible Ag is less efficient in cross-presentation because of diminished translocation into the cytosol, supporting the “unfolded Ag” theory.
We also show that HSP70 inhibitors block both endogenous and cross-presentation.
ImageStream analysis revealed that the inhibition in cross-presentation is not due to blocking of Ag translocation because a HSP70 inhibitor rather facilitates the translocation, which is in marked contrast to the effect of an HSP90 inhibitor that blocks Ag translocation.
Our results indicate that Ag translocation to the cytosol in cross-presentation is differentially regulated by HSP70 and HSP90.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kato, Yu& Kajiwara, Chiaki& Ishige, Ikuo& Mizukami, Shusaku& Yamazaki, Chihiro& Eikawa, Shingo…[et al.]. 2012. HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kato, Yu…[et al.]. HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation. Autoimmune Diseases No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kato, Yu& Kajiwara, Chiaki& Ishige, Ikuo& Mizukami, Shusaku& Yamazaki, Chihiro& Eikawa, Shingo…[et al.]. HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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