A New MAP Kinase Protein Involved in Estradiol-Stimulated Reproduction of the Helminth Parasite Taenia crassiceps
المؤلفون المشاركون
Hallal-Calleros, Claudia
Morales-Montor, Jorge
Escobedo, Galileo
Chávez-Ríos, Jesús Ramsés
Ortega-Pierres, Guadalupe
Fonseca-Liñán, Rocío
Soldevila, Gloria
Ostoa-Saloma, Pedro
Nava, Karen
López-Griego, Lorena
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-01-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
MAP kinases (MAPK) are involved in the regulation of cellular processes such as reproduction and growth.
In parasites, the role of MAPK has been scarcely studied.
Here, we describe the participation of an ERK-like protein in estrogen-dependent reproduction of the helminth parasite Taenia crassiceps.
Our results show that 17β-estradiol induces a concentration-dependent increase in the bud number of in vitro cultured cysticerci.
If parasites are also incubated in presence of an ERK-inhibitor, the stimulatory effect of estrogen is blocked.
The expression of ERK-like mRNA and its corresponding protein was detected in the parasite.
The ERK-like protein was over-expressed by all treatments.
Nevertheless, a strong induction of phosphorylation of this protein was observed only in response to 17β-estradiol.
Cross-contamination by host cells was discarded by flow cytometry analysis.
Parasite cells expressing the ERK-like protein were exclusively located at the subtegument tissue by confocal microscopy.
Finally, the ERK-like protein was separated by bidimensional electrophoresis and then sequenced, showing the conserved TEY activation motif, typical of all known ERK 1/2 proteins.
Our results show that an ERK-like protein is involved in the molecular signalling during the interaction between the host and T.
crassiceps, and may be considered as target for anti-helminth drugs design.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Escobedo, Galileo& Soldevila, Gloria& Ortega-Pierres, Guadalupe& Chávez-Ríos, Jesús Ramsés& Nava, Karen& Fonseca-Liñán, Rocío…[et al.]. 2010. A New MAP Kinase Protein Involved in Estradiol-Stimulated Reproduction of the Helminth Parasite Taenia crassiceps. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-495475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Escobedo, Galileo…[et al.]. A New MAP Kinase Protein Involved in Estradiol-Stimulated Reproduction of the Helminth Parasite Taenia crassiceps. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-495475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Escobedo, Galileo& Soldevila, Gloria& Ortega-Pierres, Guadalupe& Chávez-Ríos, Jesús Ramsés& Nava, Karen& Fonseca-Liñán, Rocío…[et al.]. A New MAP Kinase Protein Involved in Estradiol-Stimulated Reproduction of the Helminth Parasite Taenia crassiceps. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-495475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر