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Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection : From Thymocyte Depletion to Differential Cell ExpansionContraction in Peripheral Lymphoid Organs
المؤلفون المشاركون
Morrot, Alexandre
Barreto de Albuquerque, Juliana
de Meis, Juliana
Savino, Wilson
de Carvalho Pinto, Carla Eponina
Berbert, Luiz Ricardo
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The comprehension of the immune responses in infectious diseases is crucial for developing novel therapeutic strategies.
Here, we review current findings on the dynamics of lymphocyte subpopulations following experimental acute infection by Trypanosoma cruzi, the causative agent of Chagas disease.
In the thymus, although the negative selection process of the T-cell repertoire remains operational, there is a massive thymocyte depletion and abnormal release of immature CD4+CD8+ cells to peripheral lymphoid organs, where they acquire an activated phenotype similar to activated effector or memory T cells.
These cells apparently bypassed the negative selection process, and some of them are potentially autoimmune.
In infected animals, an atrophy of mesenteric lymph nodes is also observed, in contrast with the lymphocyte expansion in spleen and subcutaneous lymph nodes, illustrating a complex and organ specific dynamics of lymphocyte subpopulations.
Accordingly, T- and B-cell activation is seen in subcutaneous lymph nodes and spleen, but not in mesenteric lymph nodes.
Lastly, although the function of peripheral CD4+CD8+ T-cell population remains to be defined in vivo, their presence may contribute to the immunopathological events found in both murine and human Chagas disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morrot, Alexandre& Barreto de Albuquerque, Juliana& Berbert, Luiz Ricardo& de Carvalho Pinto, Carla Eponina& de Meis, Juliana& Savino, Wilson. 2012. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection : From Thymocyte Depletion to Differential Cell ExpansionContraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-495478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morrot, Alexandre…[et al.]. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection : From Thymocyte Depletion to Differential Cell ExpansionContraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-495478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morrot, Alexandre& Barreto de Albuquerque, Juliana& Berbert, Luiz Ricardo& de Carvalho Pinto, Carla Eponina& de Meis, Juliana& Savino, Wilson. Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection : From Thymocyte Depletion to Differential Cell ExpansionContraction in Peripheral Lymphoid Organs. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-495478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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