Lower Extremity Ulcers in Systemic Sclerosis : Features and Response to Therapy
المؤلفون المشاركون
Price, Patricia
Steen, Virginia D.
Shanmugam, Victoria K.
Attinger, Christopher E.
المصدر
International Journal of Rheumatology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-08-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nondigital lower extremity ulcers are a difficult to treat complication of scleroderma, and a significant cause of morbidity.
The purpose of this study was to evaluate the prevalence of nondigital lower extremity ulcers in scleroderma and describe the associations with autoantibodies and genetic prothrombotic states.
A cohort of 249 consecutive scleroderma patients seen in the Georgetown University Hosptial Division of Rheumatology was evaluated, 10 of whom had active ulcers, giving a prevalence of 4.0%.
Patients with diffuse scleroderma had shorter disease duration at the time of ulcer development (mean 4.05 years ± 0.05) compared to those with limited disease (mean 22.83 years ± 5.612, P value .0078).
Ulcers were bilateral in 70%.
In the 10 patients with ulcers, antiphospholipid antibodies were positive in 50%, and genetic prothrombotic screen was positive in 70% which is higher than expected based on prevalence reports from the general scleroderma population.
Of patients with biopsy specimens available (n=5), fibrin occlusive vasculopathy was seen in 100%, and all of these patients had either positive antiphospholipid antibody screen, or positive genetic prothrombotic profile.
We recommend screening scleroderma patients with lower extremity ulcers for the presence of anti-phospholipid antibodies and genetic prothrombotic states.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shanmugam, Victoria K.& Price, Patricia& Attinger, Christopher E.& Steen, Virginia D.. 2010. Lower Extremity Ulcers in Systemic Sclerosis : Features and Response to Therapy. International Journal of Rheumatology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shanmugam, Victoria K.…[et al.]. Lower Extremity Ulcers in Systemic Sclerosis : Features and Response to Therapy. International Journal of Rheumatology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-495527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shanmugam, Victoria K.& Price, Patricia& Attinger, Christopher E.& Steen, Virginia D.. Lower Extremity Ulcers in Systemic Sclerosis : Features and Response to Therapy. International Journal of Rheumatology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-495527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر