Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients
المؤلفون المشاركون
Yang, Ming Ming
Liu, Guo Dong
Wang, Jun
Teng, Yan
Li, Yan Bo
Liu, Xiao Min
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
The complement system is a key component of innate immunity and has been implicated in the pathogenesis of diabetic retinopathy (DR).
This study aimed at investigating whether polymorphisms of two genes in the complement pathway, complement factor H (CFH) and complement factor B (CFB), are associated with DR.
Methods.
552 well-defined subjects with type 2 diabetes, consisting of 277 DR patients and 275 diabetic controls, were recruited.
Four Tag-SNPs rs1048709, rs537160, rs4151657, and rs2072633 in CFB and rs800292 (I62V) in CFH were examined using TaqMan Genotyping Assays.
Results.
There were significant increases in the frequencies of A allele and AA genotype for rs1048709 in DR patients compared with diabetic controls (Pcorr=0.035, OR=1.42; Pcorr=0.02, OR=2.27, resp.): meanwhile, significant decreases in the frequencies of A allele and AA genotype for rs800292 were observed in DR patients compared with diabetic controls (Pcorr=0.04, OR=0.72; Pcorr=0.015, OR=0.51, resp.).
Joint effect of these two loci was also identified.
Moreover, rs800292/AA genotype was found to be related with delayed progression to DR.
Conclusions.
CFH-rs800292 and CFB-rs1048709 are associated with the presence of DR, which strengthens the concept that complement system plays an important role in the pathogenesis of DR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jun& Yang, Ming Ming& Li, Yan Bo& Liu, Guo Dong& Teng, Yan& Liu, Xiao Min. 2013. Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495580
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jun…[et al.]. Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-495580
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jun& Yang, Ming Ming& Li, Yan Bo& Liu, Guo Dong& Teng, Yan& Liu, Xiao Min. Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495580
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495580
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر