Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway
المؤلفون المشاركون
Yachie, Akihiro
Koizumi, Shoichi
Saito, Takekatsu
Nakamura, Taichi
Ohta, Kunio
Shimizu, Tohru
Nakayama, Yuko
Sugimoto, Naotoshi
Nakamura, Hiroyuki
Ohtani, Kaori
Hitomi, Yashiaki
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Specific strains of Lactobacillus have been found to be beneficial in treating some types of diarrhea and vaginosis.
However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia.
Cyclic AMP (cAMP) is a small second messenger molecule that mediates signal transduction.
The onset and progression of inflammatory responses are sensitive to changes in steady-state cAMP levels.
L.
casei cell wall extract (LCWE) develops arteritis in mice through Toll-like receptor-2 signaling.
The purpose of this study was to investigate whether intracellular cAMP affects LCWE-induced pathological signaling.
LCWE was shown to induce phosphorylation of the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways and cell proliferation in mice fibroblast cells.
Theophylline and phosphodiesterase inhibitor increased intracellular cAMP and inhibited LCWE-induced cell proliferation as well as phosphorylation of NF-κB and MAPK.
Protein kinase A inhibitor H89 prevented cAMP-induced MAPK inhibition, but not cAMP-induced NF-κB inhibition.
An exchange protein activated by cAMP (Epac) agonist inhibited NF-κB activation but not MAPK activation.
These results indicate that an increase in intracellular cAMP prevents LCWE induction of pathological signaling pathways dependent on PKA and Epac signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saito, Takekatsu& Sugimoto, Naotoshi& Ohta, Kunio& Shimizu, Tohru& Ohtani, Kaori& Nakayama, Yuko…[et al.]. 2012. Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saito, Takekatsu…[et al.]. Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-495591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saito, Takekatsu& Sugimoto, Naotoshi& Ohta, Kunio& Shimizu, Tohru& Ohtani, Kaori& Nakayama, Yuko…[et al.]. Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر