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Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors : A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial
المؤلفون المشاركون
Völker, Birgit
Ruilope, Luis M.
Bays, Harold
Zhu, Dingliang
Mattheus, Michaela
Gao, Pingjin
المصدر
International Journal of Hypertension
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
Report of prespecified and post hoc subgroup analyses of a randomized, controlled trial comparing telmisartan 80 mg/hydrochlorothiazide 25 mg (T80/H25) combination therapy with T80 monotherapy, according to the presence of cardiovascular disease (CVD) risk factors.
Methods.
Hypertensive patients were randomized (2 : 1) to receive T80/H25 or T80 for 6 weeks, following a 1-week, low-dose, and run-in period.
Systolic blood pressure (SBP) and diastolic BP reductions and BP goal achievement were evaluated in patients with CVD risk factors: presence of diabetes mellitus (DM), renal impairment, increased body mass index (BMI), and 10-year estimated risk for coronary heart disease (CHD).
Results.
In total, 888 patients received treatment.
Overall, T80/H25 therapy significantly reduced SBP more than T80 monotherapy, irrespective of patient subgroup.
In patients with DM, renal impairment, high BMI, and high CHD risk, BP goal achievement rates (<140/90 mm Hg) at Week 7, among those treated with T80/H25, were 52.8%, 52.8%, 50.6%, and 38.5%, respectively.
More patients with DM reached a guideline-based BP goal (<130/80 mm Hg) at 7 weeks with T80/H25 than with T80 monotherapy (16.7% versus 8.8%).
Rates of treatment-related adverse events were low and comparable across patient subgroups.
Conclusions.
Antihypertensive treatment with T80/H25 single-pill combination is effective and generally well tolerated, irrespective of the presence of CVD risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bays, Harold& Gao, Pingjin& Völker, Birgit& Mattheus, Michaela& Ruilope, Luis M.& Zhu, Dingliang. 2013. Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors : A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-495719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bays, Harold…[et al.]. Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors : A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial. International Journal of Hypertension No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-495719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bays, Harold& Gao, Pingjin& Völker, Birgit& Mattheus, Michaela& Ruilope, Luis M.& Zhu, Dingliang. Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors : A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-495719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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