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The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells
المؤلفون المشاركون
Pan, Bo-Syong
Lin, Chun-Yu
Huang, Bu-Miin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Cordycepin is a natural pure compound extracted from Cordyceps sinensis (CS).
We have demonstrated that CS stimulates steroidogenesis in primary mouse Leydig cell and activates apoptosis in MA-10 mouse Leydig tumor cells.
It is highly possible that cordycepin is the main component in CS modulating Leydig cell functions.
Thus, our aim was to investigate the steroidogenic and apoptotic effects with potential mechanism of cordycepin on MA-10 mouse Leydig tumor cells.
Results showed that cordycepin significantly stimulated progesterone production in dose- and time-dependent manners.
Adenosine receptor (AR) subtype agonists were further used to treat MA-10 cells, showing that A1, A 2A , A 2B , and A3, AR agonists could stimulate progesterone production.
However, StAR promoter activity and protein expression remained of no difference among all cordycepin treatments, suggesting that cordycepin might activate AR, but not stimulated StAR protein to regulate MA-10 cell steroidogenesis.
Meanwhile, cordycepin could also induce apoptotic cell death in MA-10 cells.
Moreover, four AR subtype agonists induced cell death in a dose-dependent manner, and four AR subtype antagonists could all rescue cell death under cordycepin treatment in MA-10 cells.
In conclusion, cordycepin could activate adenosine subtype receptors and simultaneously induce steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Bo-Syong& Lin, Chun-Yu& Huang, Bu-Miin. 2011. The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-495772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Bo-Syong…[et al.]. The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-495772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Bo-Syong& Lin, Chun-Yu& Huang, Bu-Miin. The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-495772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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