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Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4-Induced Acute Liver Lipid Accumulation in Rats
المؤلفون المشاركون
Chae, Han-Jung
Kim, Hyung-Ryong
Yadav, Raj-Kumar
Li, Bo
Lin, Shun-Mei
Jin, Chang-Feng
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Eucommia ulmoides Oliv.
(EU) has been used for treatment of liver diseases.
The protective effects of Eucommia Ulmoides Oliv.
cortex extracts (EUCE) on the carbon tetrachloride- (CCl4-) induced hepatic lipid accumulation were examined in this study.
Rats were orally treated with EUCE in different doses prior to an intraperitoneal injection of 1 mg/kg CCl4.
Acute injection of CCl4 decreased plasma triglyceride but increased hepatic triglyceride and cholesterol as compared to control rats.
On the other hand, the pretreatment with EUCE diminished these effects at a dose-dependent manner.
CCl4 treatment decreased glutathione (GSH) and increased malondialdehyde (MDA) accompanied by activated P450 2E1.
The pretreatment with EUCE significantly improved these deleterious effects of CCl4.
CCl4 treatment increased P450 2E1 activation and ApoB accumulation.
Pretreatment with EUCE reversed these effects.
ER stress response was significantly increased by CCl4, which was inhibited by EUCE.
One of the possible ER stress regulatory mechanisms, lysosomal activity, was examined.
CCl4 reduced lysosomal enzymes that were reversed with the EUCE.
The results indicate that oral pretreatment with EUCE may protect liver against CCl4-induced hepatic lipid accumulation.
ER stress and its related ROS regulation are suggested as a possible mechanism in the antidyslipidemic effect of EUCE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Chang-Feng& Li, Bo& Lin, Shun-Mei& Yadav, Raj-Kumar& Kim, Hyung-Ryong& Chae, Han-Jung. 2013. Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4-Induced Acute Liver Lipid Accumulation in Rats. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-495893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Chang-Feng…[et al.]. Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4-Induced Acute Liver Lipid Accumulation in Rats. International Journal of Endocrinology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-495893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Chang-Feng& Li, Bo& Lin, Shun-Mei& Yadav, Raj-Kumar& Kim, Hyung-Ryong& Chae, Han-Jung. Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4-Induced Acute Liver Lipid Accumulation in Rats. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-495893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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