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Follistatin-Like 1 : A Potential Mediator of Inflammation in Obesity
المؤلفون المشاركون
Yin, Jiajing
Wang, Yufan
Shen, Weiqin
Sun, Haiyan
Fan, Nengguang
Zhang, Lijuan
Peng, Yongde
Wang, Yifei
Hou, Yanqiang
Liu, Rui
Xia, Zhenhua
Peng, Liang
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes.
However, the molecular mechanisms that link obesity to inflammation are not fully understood.
Follistatin-like 1 (FSTL1) is a novel proinflammatory cytokine that is expressed in adipose tissue and secreted by preadipocytes/adipocytes.
We aimed to test whether FSTL1 could have a role in obesity-induced inflammation and insulin resistance.
It was found that FSTL1 expression was markedly decreased during differentiation of 3T3-L1 preadipocytes but reinduced by TNF-α.
Furthermore, a significant increase in FSTL1 levels was observed in adipose tissue of obese ob/ob mice, as well as in serum of overweight/obese subjects.
Mechanistic studies revealed that FSTL1 induced inflammatory responses in both 3T3-L1 adipocytes and RAW264.7 macrophages.
The expression of proinflammatory mediators including IL-6, TNF-α, and MCP-1 was upregulated by recombinant FSTL1 in a dose-dependent manner, paralleled with activation of the IKKβ-NFκB and JNK signaling pathways in the two cell lines.
Moreover, FSTL1 impaired insulin signaling in 3T3-L1 adipocytes, as revealed by attenuated phosphorylation of both Akt and IRS-1 in response to insulin stimulation.
Together, our results suggest that FSTL1 is a potential mediator of inflammation and insulin resistance in obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Nengguang& Sun, Haiyan& Wang, Yufan& Wang, Yifei& Zhang, Lijuan& Xia, Zhenhua…[et al.]. 2013. Follistatin-Like 1 : A Potential Mediator of Inflammation in Obesity. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Nengguang…[et al.]. Follistatin-Like 1 : A Potential Mediator of Inflammation in Obesity. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-495951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Nengguang& Sun, Haiyan& Wang, Yufan& Wang, Yifei& Zhang, Lijuan& Xia, Zhenhua…[et al.]. Follistatin-Like 1 : A Potential Mediator of Inflammation in Obesity. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-495951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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